iPSC Scientist – In Vitro Pharmacology

About the role

We are seeking an experienced iPSC Scientist to join our in‑vitro pharmacology department. The role focuses on developing and applying CNS/PNS organoid models for disease modelling and drug screening.

Key responsibilities

• Establish and maintain iPSC cultures and differentiate them into neural cell types in 2D and 3D formats.
• Design, set up, and validate quantitative assays (e.g., MEA, calcium imaging, flow cytometry, ELISA, MSD) using organoid models.
• Perform molecular biology workflows including plasmid design, qPCR, ddPCR, and CRISPR guide design.
• Generate and analyse transcriptomic data (scRNA‑seq, spatial transcriptomics, RNA‑seq).
• Collaborate with internal teams and external partners to integrate state‑of‑the‑art technologies.

Required profile

• Master’s or PhD in cell biology, neuroscience, or a related field.
• Proven experience creating neural organoid models from iPSC for disease modelling or pharmacology.
• Strong track record of delivering high‑quality data in a fast‑paced research environment.
• Excellent communication, organization, and teamwork skills.

Required skills

• iPSC culture and neural differentiation (2D & 3D)
• 3D organoid handling
• Molecular biology: plasmid design, qPCR, ddPCR
• Transcriptomics: scRNA‑seq, spatial transcriptomics, RNA‑seq
• Functional assays: MEA, calcium imaging, flow cytometry, ELISA, MSD, immunofluorescence
• Viral vector transduction (AAV, lentivirus)
• High‑content and confocal microscopy
• CRISPR guide design