Senior Manager – R&D Clinical Operations & Portfolio Strategy (Pharma)

About the role

We are looking for an experienced Manager or Senior Manager to lead R&D Clinical Operations and Portfolio Strategy projects for pharmaceutical and life‑science clients. Based in our Brussels office, you will work within PwC Advisory’s R&D & Quality group, helping clients optimise clinical trial delivery, strengthen portfolio governance and drive digital transformation.

Key responsibilities

• Lead complex engagements covering clinical operations, portfolio strategy and digital initiatives for pharma clients.
• Design and optimise operating models for trial execution and governance frameworks.
• Support implementation of CTMS, eTMF, RBQM platforms and advanced analytics tools.
• Provide guidance on regulatory expectations (ICH GCP, EU CTR, FDA IND) and industry best practices.
• Develop proposals, statements of work and high‑quality deliverables while supporting business development.
• Mentor junior consultants and contribute to knowledge development.

Required profile

• 7–9 years of experience in clinical operations, portfolio governance or related consulting.
• Proven ability to manage client relationships and deliver strategic recommendations.
• Strong analytical mindset and familiarity with digital transformation in clinical research.

Required skills

• Clinical trial management systems (CTMS)
• Electronic trial master file (eTMF)
• Risk‑based quality management (RBQM) platforms
• Advanced analytics for portfolio decision‑making
• Regulatory frameworks: ICH GCP, EU CTR, FDA IND

What we offer

• Opportunity to work on high‑impact projects within a global professional services firm.
• Collaborative environment with access to industry experts and cutting‑edge technologies.
• Continuous learning and development programmes.